José Manuel
Brea Floriani
Profesor titular de universidad
EDDY
SOTELO PEREZ
Catedrático de universidad
Publicaciones en las que colabora con EDDY SOTELO PEREZ (31)
2024
-
Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
Biomedicine and Pharmacotherapy, Vol. 173
-
N-Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R)
Journal of Medicinal Chemistry, Vol. 67, Núm. 13, pp. 11003-11023
2023
-
A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery
Molecules, Vol. 28, Núm. 24
-
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 235-250
-
Exploring the Effect of Halogenation in a Series of Potent and Selective A2BAdenosine Receptor Antagonists
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 890-912
-
Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
Frontiers in Molecular Biosciences, Vol. 10
-
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
European Journal of Medicinal Chemistry, Vol. 248
-
Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs
Biomedicine and Pharmacotherapy, Vol. 164
2022
-
A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Journal for ImmunoTherapy of Cancer, Vol. 10, Núm. 5
-
Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3Antagonists
ACS Medicinal Chemistry Letters, Vol. 13, Núm. 2, pp. 243-249
-
Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands
Biomedicine and Pharmacotherapy, Vol. 153
-
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1Antagonists
Journal of Medicinal Chemistry, Vol. 65, Núm. 3, pp. 2091-2106
2021
-
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480
2020
-
Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists
Journal of medicinal chemistry, Vol. 63, Núm. 14, pp. 7721-7739
2019
-
Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition
Journal of Medicinal Chemistry, Vol. 62, Núm. 20, pp. 9315-9330
2018
-
Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke
Annals of Neurology, Vol. 84, Núm. 2, pp. 260-273
2017
-
3-Oxopyridazin-5-yl-Chalcone Hybrids: Potent Antiplatelet Agents That Prevent Glycoprotein IIb/IIIa Activation
ChemistrySelect, Vol. 2, Núm. 17, pp. 4920-4933
-
Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases
Journal of Cheminformatics, Vol. 9, Núm. 1
-
Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
Scientific Reports, Vol. 7, Núm. 1
-
Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists
Journal of Medicinal Chemistry, Vol. 60, Núm. 17, pp. 7502-7511