José Manuel
Brea Floriani
Senior university lecturer
María Isabel
Loza García
University professor
Publications by the researcher in collaboration with María Isabel Loza García (162)
2024
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Effect of Bulky N-Dibenzofuranylmethyl Substitution on the 5-HT2 Receptor Affinity and Efficacy of a Psychedelic Phenethylamine
ACS Chemical Neuroscience, Vol. 15, Núm. 3, pp. 608-616
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Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
Biomedicine and Pharmacotherapy, Vol. 173
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High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries
SLAS Discovery, Vol. 29, Núm. 3
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In vitro models for neuropathic pain phenotypic screening in brain therapeutics
Pharmacological Research, Vol. 202
2023
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8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies
European Journal of Medicinal Chemistry, Vol. 248
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A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery
Molecules, Vol. 28, Núm. 24
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A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry
Archives of Toxicology, Vol. 97, Núm. 4, pp. 1091-1111
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Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 235-250
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Exploring the Effect of Halogenation in a Series of Potent and Selective A2BAdenosine Receptor Antagonists
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 890-912
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Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
Frontiers in Molecular Biosciences, Vol. 10
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N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
European Journal of Medicinal Chemistry, Vol. 248
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Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs
Biomedicine and Pharmacotherapy, Vol. 164
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Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
Frontiers in Immunology, Vol. 14
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Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors
ACS Medicinal Chemistry Letters, Vol. 14, Núm. 12, pp. 1656-1663
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Una experiencia sobre la utilización de una plantilla basada en el método Canvas para el aprendizaje semipresencial en un máster de desarrollo de medicamentos
Actualidad en farmacología y terapéutica, Vol. 21, Núm. 2, pp. 142-149
2022
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2-(Fluoromethoxy)-4′-(S-methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1Receptor for Parkinson's Disease
Journal of Medicinal Chemistry, Vol. 65, Núm. 18, pp. 12256-12272
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A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Journal for ImmunoTherapy of Cancer, Vol. 10, Núm. 5
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A New Family of Subnanomolar inhibitors of Soluble Epoxide Hydrolase
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 36
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An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery
International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267
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Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 236