MARTA MARIA
VARELA REY
Investigadora distinguida
Ikerbasque, Fundación Vasca para la Ciencia
Bilbao, EspañaPublicacións en colaboración con investigadores/as de Ikerbasque, Fundación Vasca para la Ciencia (20)
2024
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Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination
Science Advances, Vol. 10, Núm. 15
2023
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Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, Vol. 77, Núm. 5, pp. 1654-1669
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Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
Cell Metabolism, Vol. 35, Núm. 8, pp. 1373-1389.e8
2022
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HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
Advanced Drug Delivery Reviews, Vol. 181
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Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
Nature Communications, Vol. 13, Núm. 1
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Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
Hepatology, Vol. 75, Núm. 3, pp. 550-566
2021
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Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
JHEP Reports, Vol. 3, Núm. 3
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E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment
Cancer Research, Vol. 81, Núm. 11, pp. 2874-2887
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O-GlcNAcylated p53 in the liver modulates hepatic glucose production
Nature Communications, Vol. 12, Núm. 1
2020
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Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
Nature Communications, Vol. 11, Núm. 1
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Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
Cell Metabolism, Vol. 31, Núm. 3, pp. 605-622.e10
2019
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miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Molecular Metabolism, Vol. 29, pp. 40-54
2018
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MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
Cell Death and Disease, Vol. 9, Núm. 10
2017
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Role of aramchol in steatohepatitis and fibrosis in mice
Hepatology Communications, Vol. 1, Núm. 9, pp. 911-927
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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
Nature Communications, Vol. 8, Núm. 1
2016
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Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis
Journal of Hepatology, Vol. 64, Núm. 2, pp. 409-418
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Stratification and therapeutic potential of PML in metastatic breast cancer
Nature Communications, Vol. 7
2015
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Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves
Journal of Cell Biology, Vol. 210, Núm. 1, pp. 153-168
2014
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S-adenosylmethionine levels regulate the schwann cell DNA methylome
Neuron, Vol. 81, Núm. 5, pp. 1024-1039
2012
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Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
Hepatology, Vol. 55, Núm. 4, pp. 1237-1248