Mecanismos moleculares da enfermedade
MeMoEn
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University of Cambridge
Cambridge, Reino UnidoPublicacións en colaboración con investigadores/as de University of Cambridge (15)
2024
2023
2021
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Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases
Nature Medicine, Vol. 27, Núm. 9, pp. 1564-1575
2020
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Metabolic effects of bezafibrate in mitochondrial disease
EMBO Molecular Medicine, Vol. 12, Núm. 3
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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Nature Genetics, Vol. 52, Núm. 3, pp. 306-319
2019
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Hypothalamic dopamine signalling regulates brown fat thermogenesis
Nature Metabolism, Vol. 1, Núm. 8, pp. 811-829
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MCH regulates SIRT1/FoxO1 and reduces POMC neuronal activity to induce hyperphagia, adiposity, and glucose intolerance
Diabetes, Vol. 68, Núm. 12, pp. 2210-2222
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Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development
Blood Advances, Vol. 3, Núm. 16, pp. 2499-2511
2018
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Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family
Brain, Vol. 141, Núm. 1, pp. 55-62
2017
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Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations
PLoS Genetics, Vol. 13, Núm. 12
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Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ
Journal of Allergy and Clinical Immunology, Vol. 140, Núm. 5, pp. 1461-1464.e8
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Mutations in mitochondrial DNA causing tubulointerstitial kidney disease
PLoS Genetics, Vol. 13, Núm. 3
2015
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Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming
Cell Stem Cell, Vol. 16, Núm. 6, pp. 653-668
2013
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NANOG-dependent function of TET1 and TET2 in establishment of pluripotency
Nature, Vol. 495, Núm. 7441, pp. 370-374
2012
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Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Núm. 40, pp. 16202-16207