![Foto de José Manuel](/img/nophoto.png)
José Manuel
Otero Casas
Publications by the researcher in collaboration with José Manuel Otero Casas (14)
2023
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Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme—A molecular insight †
Frontiers in Molecular Biosciences, Vol. 10
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β-Peptides incorporating polyhydroxylated cyclohexane β-amino acid: synthesis and conformational study
Organic and Biomolecular Chemistry, Vol. 21, Núm. 42, pp. 8535-8547
2019
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Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme
Organic Chemistry Frontiers, Vol. 6, Núm. 17, pp. 3127-3135
2015
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Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct
Journal of the American Chemical Society, Vol. 137, Núm. 29, pp. 9333-9343
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Irreversible covalent modification of type i dehydroquinase with a stable Schiff base
Organic and Biomolecular Chemistry, Vol. 13, Núm. 3, pp. 706-716
2014
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Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors
Journal of Medicinal Chemistry, Vol. 57, Núm. 8, pp. 3494-3510
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Insights into substrate binding and catalysis in bacterial type i dehydroquinase
Biochemical Journal, Vol. 462, Núm. 3, pp. 415-424
2013
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Design, synthesis, and structural analysis of turn modified cyclo-(αβ3αβ2α)2 peptide derivatives toward crystalline hexagon-shaped cationic nanochannel assemblies
Crystal Growth and Design, Vol. 13, Núm. 10, pp. 4355-4367
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Mechanistic basis of the inhibition of type II dehydroquinase by (2 S)- and (2 R)-2-benzyl-3-dehydroquinic acids
ACS Chemical Biology, Vol. 8, Núm. 3, pp. 568-577
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Mycobacterium tuberculosis shikimate kinase inhibitors: Design and simulation studies of the catalytic turnover
Journal of the American Chemical Society, Vol. 135, Núm. 33, pp. 12366-12376
2011
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A prodrug approach for improving antituberculosis activity of potent mycobacterium tuberculosis type II dehydroquinase inhibitors
Journal of Medicinal Chemistry, Vol. 54, Núm. 17, pp. 6063-6084
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Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of TypeII Dehydroquinase
ChemMedChem, Vol. 6, Núm. 2, pp. 266-272
2010
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Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues
Journal of Medicinal Chemistry, Vol. 53, Núm. 1, pp. 191-200
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Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids
ChemMedChem, Vol. 5, Núm. 10, pp. 1726-1733