I+D de fármacos
GI-1606
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Universidad de La Rioja
Logroño, EspañaPublicacións en colaboración con investigadores/as de Universidad de La Rioja (8)
2022
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Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
Journal of the American Chemical Society, Vol. 144, Núm. 12, pp. 5284-5294
2019
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Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents
Nature Protocols, Vol. 14, Núm. 1, pp. 86-99
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Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
ACS Central Science, Vol. 5, Núm. 8, pp. 1417-1424
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Lysine Bioconjugation on Native Albumin with a Sulfonyl Acrylate Reagent
Methods in Molecular Biology (Humana Press Inc.), pp. 25-37
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Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
Angewandte Chemie - International Edition, Vol. 58, Núm. 20, pp. 6640-6644
2018
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Chemo- and Regioselective Lysine Modification on Native Proteins
Journal of the American Chemical Society, Vol. 140, Núm. 11, pp. 4004-4017
2017
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Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation
Journal of the American Chemical Society, Vol. 139, Núm. 50, pp. 18365-18375
2016
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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
Nature Communications, Vol. 7