I+D de fármacos
GI-1606
![Foto de Santiago](/img/nophoto.png)
Santiago
Vilar Varela
Publicacións nas que colabora con Santiago Vilar Varela (47)
2020
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Adenosine receptor ligands: Coumarin–Chalcone hybrids as modulating agents on the activity of hARs
Molecules, Vol. 25, Núm. 18
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Exploring the multi-target performance of mitochondriotropic antioxidants against the pivotal Alzheimer’s disease pathophysiological hallmarks
Molecules, Vol. 25, Núm. 2
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Structure-Based Optimization of Coumarin hA3 Adenosine Receptor Antagonists
Journal of Medicinal Chemistry, Vol. 63, Núm. 5, pp. 2577-2587
2019
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In silico prediction of P-glycoprotein binding: Insights from molecular docking studies
Current Medicinal Chemistry, Vol. 26, Núm. 10, pp. 1746-1760
2018
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Coumarins and adenosine receptors: New perceptions in structure–affinity relationships
Chemical Biology and Drug Design, Vol. 91, Núm. 1, pp. 245-256
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Hydroxybenzoic acid derivatives as dual-target ligands: Mitochondriotropic antioxidants and cholinesterase inhibitors
Frontiers in Chemistry, Vol. 6, Núm. APR
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Ligand and structure-based modeling of passive diffusion through the blood-brain barrier
Current Medicinal Chemistry, Vol. 25, Núm. 9, pp. 1073-1089
2017
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MAO inhibitory activity of bromo-2-phenylbenzofurans: Synthesis,: in vitro study, and docking calculations
MedChemComm, Vol. 8, Núm. 9, pp. 1788-1796
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Molecular docking and drug discovery in β-adrenergic receptors
Current Medicinal Chemistry, Vol. 24, Núm. 39, pp. 4340-4359
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New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies
Bioorganic and Medicinal Chemistry, Vol. 25, Núm. 5, pp. 1687-1695
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Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors
European Journal of Medicinal Chemistry, Vol. 139, pp. 1-11
2016
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Computational Drug Target Screening through Protein Interaction Profiles
Scientific Reports, Vol. 6
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Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core
MedChemComm, Vol. 7, Núm. 5, pp. 845-852
2015
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Design and discovery of tyrosinase inhibitors based on a coumarin scaffold
RSC Advances, Vol. 5, Núm. 114, pp. 94227-94235
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Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold
Bioorganic Chemistry, Vol. 61, pp. 1-6
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Navigating in chromone chemical space: Discovery of novel and distinct A3 adenosine receptor ligands
RSC Advances, Vol. 5, Núm. 96, pp. 78572-78585
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Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives
Bioorganic and Medicinal Chemistry Letters, Vol. 25, Núm. 3, pp. 642-648
2014
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Insight into the functional and structural properties of 3-arylcoumarin as an interesting scaffold in monoamine oxidase B inhibition
ChemMedChem, Vol. 9, Núm. 7, pp. 1488-1500
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Insight into the interactions between novel coumarin derivatives and human A3 adenosine receptors
ChemMedChem, Vol. 9, Núm. 10, pp. 2245-2253
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Monoamine oxidase (MAO) inhibitory activity: 3-phenylcoumarins versus 4-hydroxy-3-phenylcoumarins
ChemMedChem, Vol. 9, Núm. 8, pp. 1672-1676