Control da Regulación Xénica en Enfermidades
Regulación Xénica
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Universidad Autónoma de Madrid
Madrid, EspañaPublicacións en colaboración con investigadores/as de Universidad Autónoma de Madrid (34)
2023
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Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, Vol. 77, Núm. 5, pp. 1654-1669
2020
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Antioxidant, anti-inflammatory and neuroprotective profiles of novel 1,4-dihydropyridine derivatives for the treatment of alzheimer’s disease
Antioxidants, Vol. 9, Núm. 8, pp. 1-20
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Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization
Pharmacological Research, Vol. 152
2019
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Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aβ peptide
Redox Biology, Vol. 24
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Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux
Journal of Pineal Research, Vol. 67, Núm. 1
2018
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The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca 2+ dysregulation, and mitochondrial abnormalities
Journal of Neurochemistry, Vol. 145, Núm. 2, pp. 170-182
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Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy
Redox Biology, Vol. 18, pp. 173-180
2017
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ConBr, A Lectin Purified from the Seeds of Canavalia brasiliensis, Protects Against Ischemia in Organotypic Culture of Rat Hippocampus: Potential Implication of Voltage-Gated Calcium Channels
Neurochemical Research, Vol. 42, Núm. 2, pp. 347-359
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Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease
Scientific Reports, Vol. 7
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Heme-Oxygenase i and PCG-1α Regulate Mitochondrial Biogenesis via Microglial Activation of Alpha7 Nicotinic Acetylcholine Receptors Using PNU282987
Antioxidants and Redox Signaling, Vol. 27, Núm. 2, pp. 93-105
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ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia
ACS Chemical Neuroscience, Vol. 8, Núm. 1, pp. 67-81
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Inclusion complex of ITH12674 with 2-hydroxypropyl-β-cyclodextrin: Preparation, physical characterization and pharmacological effect
Carbohydrate Polymers, Vol. 157, pp. 94-104
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Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia
Redox Biology, Vol. 12, pp. 1040-1051
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NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 46, pp. 12315-12320
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Novel multitarget hybrid compounds for the treatment of alzheimer’s disease
Current Topics in Medicinal Chemistry, Vol. 17, Núm. 9, pp. 1027-1043
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Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices
Neuropharmacology, Vol. 116, pp. 110-121
2016
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Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice
Molecular Neurobiology, Vol. 53, Núm. 5, pp. 3030-3045
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Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
Pharmacology and Therapeutics, Vol. 157, pp. 84-104
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Sensory input-dependent changes in glutamatergic neurotransmission-related genes and proteins in the adult rat trigeminal ganglion
Frontiers in Molecular Neuroscience, Vol. 9, Núm. NOV2016
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Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures
Molecular Neurobiology, Vol. 53, Núm. 5, pp. 3338-3348