Efficient Multicomponent Catalyst-Free Synthesis of Substituted 2-Aminopyridines

  1. Benzenine, Djamila 12
  2. Kibou, Zahira 23
  3. Belhadj, Fatima 24
  4. Baba-Ahmed, Ikram 12
  5. Vázquez-Tato, M. Pilar 4
  6. Seijas, Julio A. 4
  7. Choukchou-Braham, Noureddine 2
  1. 1 Laboratoire de Chimie Appliquée, Centre Universitaire Belhadj Bouchaib de Ain Témouchent, B.P. 284, Ain Témouchent 46000, Algeria
  2. 2 Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P.119, Tlemcen 13000, Algeria
  3. 3 Faculté de Médecine, Université Oran 1, B.P. 1510 El Menaouar, Oran 31000, Algeria
  4. 4 Departamento de Química Orgánica, Facultad de Ciencias, Universidad of Santiago De Compostela, Alfonso X elSabio, 27002 Lugo, Spain
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Proceedings:
The 24th International Electronic Conference on Synthetic Organic Chemistry

Publisher: MDPI

ISSN: 2673-4583

Year of publication: 2020

Pages: 125

Type: Conference paper

DOI: 10.3390/ECSOC-24-08381 GOOGLE SCHOLAR lock_openOpen access editor

Abstract

2-aminopyridines scaffolds are an important class of nitrogen heterocyclic compounds with a wide range of biological activities. Multicomponent reactions (MCRs) are useful methods for the construction of nitrogen heterocyclic compounds. In this context, syntheses of 2-aminopyridines derivatives via MCRs have attracted considerable attention in recent years. We present, in this work, a rapid and efficient synthesis of 2-aminopyridine derivatives, via the catalyst-free four-component method. This protocol provides a simple and practical approach to functionalized 2-aminopyridnes from readily available substrates under solvent-free conditions.

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