Synthesis and Reactivity of 2-Acetylthiophenes Derivatives

  1. Missoum, Hadjer 1
  2. Datoussaid, Yazid 12
  3. Choukchou-braham, Noureddine 1
  4. Seijas, Julio A. 3
  5. Vázquez-Tato, Maria Pilar 3
  1. 1 Laboratory of Catalysis and Synthesis in Organic Chemistry, Faculty of Sciences, University of Tlemcen, BP119, Tlemcen 13000, Algeria
  2. 2 Higher School of Applied Sciences of Tlemcen (ESSAT), Tlemcen 13000, Algeria
  3. 3 Department of Organic Chemistry, Faculty of Sciences, University of Santiago de Compostela, 5 Campus Terra, 27080 Lugo, Spain
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Proceedings:
27th International Electronic Conference on Synthetic Organic Chemistry

Publisher: MDPI

ISSN: 2673-4583

Year of publication: 2023

Pages: 112

Type: Conference paper

DOI: 10.3390/ECSOC-27-16132 GOOGLE SCHOLAR lock_openOpen access editor

Abstract

Thiophene is a five-membered sulfur containing a heteroaromatic ring. Its presence in compounds of therapeutic interest is remarkable, leading to various studies to develop strategies to synthesize new biologically active thiophene analogues. Due to the presence of a ketone function, 2-acetylthiophenes derivatives are good intermediates to prepare such important compounds. Since its discovery, the Vilsmeier–Haack reaction has always been a subject of great interest to organic chemists and continues to attract considerable attention. It is a powerful tool in organic chemistry. This reagent is widely used for the chloroformylation of ketones leading to 3-chloroacroleins, which are scaffolds to prepare 5-aryl-2-acetylthiophenes derivatives. Our team aimed to develop and functionalize heterocyclic compounds with promising biological and pharmacological activities, including some new concepts of green chemistry; as a part of our research, different derivatives of 5-aryl-2-acetylthiophenes were achieved in good yields and then used to prepare the new compounds.

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