New supramolecular concepts for the development of functional systems in cells and protocells
- Rioboo Vidal, Alicia
- Javier Montenegro García Director
- Juan Ramón Granja Guillán Director
Universidade de defensa: Universidade de Santiago de Compostela
Ano de defensa: 2024
Tipo: Tese
Resumo
In this manuscript, we have approached the development of new functional supramolecular systems from a chemical perspective and with the objective to modify or replicate cellular functions. The main driving force and link between the systems developed during this PhD work is the dynamic character of stimuli-responsiveness, which is crucial for their specific functional behaviour. The novel functional systems development focused on a protofilament cytoskeleton-mimetic system, a new ratiometric fluorescent SNARF probe with pH range sensitivity optimized and a pH sensitive antitumoral analogue of a natural venom.