[P3–470]: COGNITIVE RESERVE (CR) AND COGNITIVE PERFORMANCE IN PEOPLE WITH SUBJECTIVE COGNITIVE COMPLAINTS (SCCS)

Resumo

BackgroundCognitive reserve (CR) is a critical factor to explain inter-individual differences in cognitive consequences of neurological damage (Stern, 2012). Education, working activity and leisure activities such as social and cultural participation have been used as proxies of CR. Increased frequency of such activities may provide the brain with more resources to enable it to adapt to damage and compensate cognitive and physical frailty. Many studies have demonstrated the protective effect of CR against the manifestations of cognitive decline (Erickson et al., 2015; Giogkaraki et al., 2013; Lojo-Seoane et al., 2014; Stern, 2012). The aims of the present work were to determine the relationship of CR, measured with Cognitive Reserve Index questionnaire (CRIq), and cognitive performance in people with subjective cognitive complaints (SCCs).MethodsA total sample of 102 participants with SCCs older than 50 years were classified into two groups: amnestic multidomain Mild Cognitive Impairment (amd-MCI) and SCCs without objective impairment (SCCs-WOI) (Table 1). Correlations between CR, age, and measures of general cognitive performance (MMSE and CAMCOG-R), episodic memory (CVLT), working memory (TMT-B), language (Boston and Verbal Fluency) and crystallized intelligence (WAIS-vocabulary) were calculated. General linear model procedures were carried out to compare groups in CR introducing age as covariate.ResultsCRIq total score correlates significantly with all measures of cognitive performance (Table 2). CRIq total score, F(1,102)=5.87, p<.05, η2p=.06, and Education-CRIq score, F(1,102)=5.09, p<.05, η2p =.05, were significantly higher for the SCCs-WOI group than for the amd-MCI group, with age as covariate. In Working activity-CRIq, F(1,102)=1.49, p=.23, η2p =.02, and Leisure time-CRIq scores, F(1,102)=3.76, p=.055, η2p =.06, the two groups were similar (Figure 1).ConclusionsCR is related to cognitive performance in several domains. Participants with SCCs without objective impairment showed more CR than participants with amd-MCI and subjective cognitive complaints. These results are relevant in the context of the evaluation and diagnosis of cognitive performance and prevention of cognitive impairment, encouraging participation in activities that increase the CR. Funding: This work was supported by the Xunta de Galicia, FrailNet network IN607C 2016/08.