P3‐214: Neuropsychiatric and Depressive Symptoms in Different Subtypes of Mild Cognitive Impairment: A Follow Up Study

Resumo

BackgroundNeuropsychiatric symptoms are common in mild cognitive impairment (MCI) (Monastero et al 2009). Depression is one of the most prevalence symptoms and has been associated with progression to Alzheimer Disease (Mussele et al 2014). The purpose of this study was to examine on time the change on neuropsychiatric and depressive symptoms in different MCI subtypes.MethodsWe evaluated 142 individuals aged +50 who attended primary care health centers with subjective cognitive complains, but without neurological or psychiatric illness. Each participant underwent extensive evaluation, including review of his or her medical history and neuropsychological assessment, and was revaluated up at approximately 15 months. Of the 142 individuals, 20 were diagnosed at the follow-up as multiple domain amnestic MCI (mda-MCI), 22 as multiple domain non amnestic MCI (mdna-MCI), 32 as single domain amnestic MCI (sda-MCI) and 68 as Healthy Controls. MCI diagnosis was made following the standard criteria (Albert et al 2011; Petersen 2004). We compared the change in the total severity score of neuropsychiatric and depressive symptoms assessed through the Neuropsychiatric Inventory-Questionnarie (NPI-Q) and the Geriatric Depression Scale (GDS), using repeated measures ANOVA with the within-subject NPI-Q and GDS scores as dependent variables, and Group (the four groups) and Evaluation (baseline and follow-up) as factors.ResultsWe found significant effects for Group and interaction Group*Evaluation in the neuropsychiatric symptoms (NPI-Q). The group mda-MCI showed higher neuropsychiatric symptoms than the other groups at baseline and an increase at the follow-up. In depressive symptoms (GDS) only significant main effects for Group and Evaluation were found. The mda-MCI and mdna-MCI groups displayed more depressive symptoms than the Healthy Controls. For all groups there was a slight increase at the follow-up.ConclusionsNeuropsychiatric and depressive symptoms are more common in patients with mda-MCI subtype, and in these patients increase significantly at relatively short follow-up evaluations. Further longitudinal research is necessary to determine the trajectory of that change and the predictive role of these symptoms on the conversion to Alzheimer Disease.