Predicting progression within the cognitive decline continuum using self‐ and partner‐reported cognitive complaints, and depressive symptomatology in Cognitively Unimpaired (CU) and Subjective Cognitive Decline (SCD) participants: Evidence from the CompAS longitudinal study

  1. Pérez‐Blanco, Lucía 1
  2. Felpete, Alba 1
  3. Nieto‐Vieites, Ana 1
  4. Mallo, Sabela Carme 1
  5. Campos‐Magdaleno, Maria 1
  6. Lojo‐Seoane, Cristina 1
  7. Juncos‐Rabadán, Onésimo 1
  8. Pereiro, Arturo X 1
  1. 1 University of Santiago de Compostela, Santiago de Compostela Spain
Alzheimer's & Dementia

ISSN: 1552-5260 1552-5279

Ano de publicación: 2023

Volume: 19

Número: S18

Tipo: Artigo

DOI: 10.1002/ALZ.075638 GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Alzheimer's & Dementia


BackgroundSelf-, informant reports and also depressive symptoms can predict the risk of cognitive decline. Our aim was to study the joint contribution of complaint reporting and depression to progression along the cognitive decline continuum to dementia.MethodA total of 246 participants [Cognitively Unimpaired (CU): n = 144; Subjective Cognitive Decline (SCD): n = 102] over 50 years from the Compostela Aging Study (CompAS) were assessed at baseline and at three follow-ups (intervals 18-24 months). A short version of the QAM was administered to assess severity of complaints. At each follow-up assessment participants were reclassified according to stability or progression. Logistic regressions were performed to predict stable and progressing CU and SCD participants at 3rd follow-up by using self-, informant- reports, agreement, and depressive symptomatology as predictive variable at baseline, 1st and 2nd follow-ups s.ResultsFor CU participants, (a) complaints at baseline predicted progression to SCD by the informant-report, and to MCI by the self-informant agreement; (b) complaints at 1st follow-up predicted progression to SCD or MCI by the self-report; (c) complaints at 2nd follow-up predicted progression to SCD by the self-report and the depressive symptomatology. For SCD participants, progression to MCI and/or dementia was only predicted by the informant-report at 2nd follow-up.ConclusionsFor CU participants, self-report was the best predictor of progression to SCD and/or MCI from the 1st follow-up. Regards SCD participants, only informant´s report was able to predict the progression to MCI and/or dementia by the end of the follow-up.