Superchaotropicity, a New Mechanism for the Intracellular Delivery of Bioactive Molecules Using Boron Clusters

  1. Giulia Salluce
Supervised by:
  1. Javier Montenegro García Director
  2. Irene Lostalé Seijo Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 09 June 2023

  1. Francisco Corzana López Chair
  2. María Tomás Gamasa Secretary
  3. Gilles Gasser Committee member
  1. Department of Organic chemistry

Type: Thesis


The internalization of bioactive molecules is a key issue in various research fields. Hydrophilic compounds do not penetrate cells unless they are assisted by a class of molecules called carriers. To date, most artificial carriers have been designed based on amphiphilicity. However, these molecules have some limitations. In this thesis, we present a new class of direct membrane transporters that leaves behind the amphiphilic paradigm. These carriers are globular boron clusters: anionic, inorganic, and water-soluble, able to interact both with the membranes and the cargo. With this project, we want to demonstrate that superchaotropic carriers could be used for a completely new mechanism of translocation across the membrane.