Pharmaceutical compounding and drug repositioning from hospital pharmacy in situations of therapeutic gap

  1. Ana Castro Balado
unter der Leitung von:
  1. Anxo Fernández Ferreiro Doktorvater/Doktormutter
  2. Francisco Javier Otero Espinar Doktorvater
  3. Miguel González Barcia Doktorvater/Doktormutter

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 08 von Mai von 2023

Gericht:
  1. José Manuel Martínez Sesmero Präsident/in
  2. Bárbara Blanco Fernández Sekretärin
  3. Mónica Climente Martí Vocal
Fachbereiche:
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Art: Dissertation

Teseo: 807995 DIALNET lock_openMINERVA editor

Zusammenfassung

This doctoral thesis focuses on offering therapeutic alternatives through pharmaceutical compounding and drug repositioning from the hospital pharmacy to cover therapeutic gaps. An ophthalmic compounded formulation of cysteamine in hyaluronic acid packaged in novel single-dose containers was developed for the treatment of ocular cystinosis. On the other hand, an inhaled compounded formulation of ethanol was developed for the treatment of SARS-CoV-2 infection, and subsequently studied for efficacy and safety in the phase II clinical trial ALCOVID-19. In both cases, appropriate galenic development and characterisation has been performed in conjunction with preclinical pharmacokinetic studies prior to appropriate translation into clinical practice.