Epigenomic characterization of circulating tumour cells in advanced colorectal cancer

  1. Aida Bao Camaño
unter der Leitung von:
  1. Angel Diaz Lagares Doktorvater/Doktormutter
  2. Rafael López López Doktorvater

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 09 von Mai von 2023

Gericht:
  1. Jesús García-Foncillas López Präsident/in
  2. Roberto Piñeiro Cid Sekretär/in
  3. Evi S. Lianidou Vocal
Fachbereiche:
  1. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina

Art: Dissertation

Zusammenfassung

Metastatic colorectal cancer continues to be a major health burden despite advances in detection and therapy. Molecular characterization of circulating tumour cells (CTCs), main drivers of the metastatic process, and the study of epigenetic mechanisms hold great promise to identify new targets for drug development and biomarkers to assess therapy response. In this frame, this thesis characterized the DNA methylome of CTCs in advanced colorectal cancer, providing new information about the biology of these cells and the metastatic process. This study also identified new potential therapeutic targets and epigenetic biomarkers that could help guide therapeutic decisions in patients with advanced disease, contributing to achieve a more personalized medicine in colorectal cancer.