Polypeptide and polyphozphazene based nanosystems for anticancer gene therapy

  1. Sheila Barrios Esteban
Dirigida por:
  1. Noemi Stefania Csaba Directora
  2. Marcos García Fuentes Director

Universidad de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 23 de marzo de 2023

Tribunal:
  1. Fabiana Quaglia Presidente/a
  2. Anxo Vidal Figueroa Secretario
  3. Maria Victoria Lozano Lopez Vocal
Departamento:
  1. Departamento de Farmacología, Farmacia y Tecnología Farmacéutica

Tipo: Tesis

Resumen

Glioblastoma and uveal melanoma are tumors without very high incidence rate, but they are characterized by being one of the most aggressive tumors with a life expectancy between 6 and 14 months. Their standard treatment is based on surgical resection followed by radiotherapy and chemotherapy triggering several severe side effects. Consequently, the search for new therapeutic approaches is required, where gene therapy stands out. However, genetic medicines require delivery systems for the protection and transport of nucleic acids to target cancer cells. In this field, nanomedicine plays an important role to the design of polymeric non-viral vectors, being very promising in gene therapy. The present work is focused on the development of tunable gene delivery nanosystems and their evaluation in different advanced preclinical cancer models