A heteronuclear ZnGd complex as a potential contrast agent for magnetic resonance imaging

  1. Fondo, Matilde 1
  2. Corredoira, Julio 1
  3. García-Deibe, Ana 1
  4. Sanmartín-Matalobos, Jesus 1
  5. Iglesias, Ramón 1
  6. Taboada, Pablo 1
  1. 1 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

Proceedings:
Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry

Year of publication: 2016

Type: Conference paper

DOI: 10.3390/ECSOC-20-B003 GOOGLE SCHOLAR lock_openOpen access editor

Abstract

A new ligand H3L, with internal compartments for allocating 3d metal ions and external donors to bind 4f ions, was synthesized and completely characterized. Reaction of H3L with zinc(II) and gadolin ium(III) salts allows isolating the heteronuclear complex {[ZnGd(HL)(NO3)(OAc)(CH3OH)](NO3)}∙6H2O (1·6H2O). The ability of 1·6H2O to act as a magnetic resonance imaging (MRI) contrast agent was evaluated and this study shows that both the transversal and longitudinal relaxivities are quite high but the T1/T2 ratio of 7.9 indicates that it could have even greater potential as a T2 contrast agent.