Bioactive Sesquiterpene Obtained from Schinus areira L. (Anacardiaceae) Essential Oil

  1. Rodriguez, Silvana 23
  2. Sueiro, Rosa Ana 1
  3. Murray, Ana Paula 3
  4. Leiro, José Manuel 2
  1. 1 Labotarorio de Microbiología, IIAA, USC, E-15782 Santiago de Compostela, Spain;
  2. 2 Laboratorio de Parasitología, IIAA, USC, E-15782 Santiago de Compostela, Spain
  3. 3 Departamento de Química, INQUISUR, UNS, B8000CPB Bahía Blanca, Argentina
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Actas:
The 23rd International Electronic Conference on Synthetic Organic Chemistry

Ano de publicación: 2019

Tipo: Achega congreso

DOI: 10.3390/ECSOC-23-06649 GOOGLE SCHOLAR lock_openAcceso aberto editor

Resumo

The essential oils (EOs) from the leaves of Schinus areira and one of its components,globulol, were studied for their antioxidant, antimutagenic and antipromutagenic activities. Thechemical composition of the EOs obtained using hydrodistillation was determined using gaschromatography-mass spectrometry (GC-MS), and fractionated using reversed phase highperformance liquid chromatography (RP-HPLC). The active compound (16.61%) isolated wasidentified by comparison of its 1H and 13C NMR spectroscopy with those reported in the literature.The antioxidant activity of the EOs and globulol were determined using two methods: crocinbleaching inhibition (Trolox Equivalent Value, TEV Krel = 1.16 ± 0.11 vs. 1.24 ± 0.22) and scavengingof the DPPH radical (IC50 = 38.75 ± 2.5 μg/mL vs. 5.60 ± 0.9 μg/mL). The antimutagenic andantipromutagenic activities were evaluated in vitro and ex vivo, using the Ames assay with fivestrains of Salmonella typhimurium with and without exogenous metabolic activation (rat liver fractionS9), against different mutagens. The result determined that globulol and EOs of S. areira at theapplied doses do not exhibit any mutagenic effect and showed the highest antioxidant activity