Determining the role of the zinc-finger protein ZMYM2 in pluripotency

  1. Souto Becerra, Yara
Dirixida por:
  1. Miguel Angel Fidalgo Pérez Director
  2. Celia María Pombo Ramos Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 22 de abril de 2022

Tribunal:
  1. Franceso Faiola Presidente/a
  2. Diana Guallar Artal Secretaria
  3. Sonia María Mulero- Navarro Vogal

Tipo: Tese

Resumo

Mutations of the zinc finger MYM-type containing 2 (ZMYM2) protein alter cellular and tissue homeostasis, but its functional roles in pluripotency are largely unexplored. Here, I show that ZMYM2 is a key component of the core regulatory network that governs pluripotency. My data reveal that ZMYM2 is a roadblock to efficient somatic cell reprogramming and is required to fine-tune the self-renewal of ESCs and the early differentiation process. Mechanistically, I found that ZMYM2 and LSD1 associate for the transcriptional control of pluripotency and differentiation genes. This study therefore establishes a novel transcriptional regulatory mode dedicated to reprogramming and pluripotency, and open new avenues for exploring the involvement of ZMYM2- LSD1 partnership in development and disease.