Formulaciones sólidas mucoadhesivas vaginales basadas en polímeros naturales para liberación sostenida de microbicidas destinadas a la prevención de la transmisión sexual del VIH

Abstract

In the absence of an effective vaccine against the human immunodeficiency virus (HIV), the Joint United Nations Program on HIV/AIDS (UNAIDS) recommends the development of stable, safe, effective and acceptable products that can successfully reduce the HIV sexual transmission. The pre-exposure prophylaxis through vaginal administered formulations can be useful for this purpose, since it provides women with an option of self-protection without the need of permission of the sexual partner. However, most clinical trials with microbicides for vaginal administration have failed in their purpose due to low adherence to treatments caused by the need of daily administration. This thesis purposes the development and characterization of vaginal formulations based on natural polymers for the sustained release of antiretroviral drugs...