New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles

  1. Velasco Rubio, Álvaro
Dirixida por:
  1. Carlos Saa Rodríguez Director
  2. Jesus Angel Varela Carrete Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 03 de decembro de 2021

Tribunal:
  1. José Luis Mascareñas Cid Presidente
  2. Mercedes Amat Tusón Secretario/a
  3. Igor Larrosa Guerrero Vogal
Departamento:
  1. Departamento de Química Orgánica

Tipo: Tese

Teseo: 694614 DIALNET lock_openMINERVA editor

Resumo

Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues. The design of new catalytic sustainable routes to these nuclei still remains as a main challenge to the organic chemistry. In this thesis the synthesis of these three nuclei upon generation of a key metalp- allyl intermediate through Csp2-H activation, allylic C-H activation, and Rh-hydride catalysis have been successfully accomplished.