Neuroprotective effects of potent antioxidant molecules isolated from Bifurcaria bifurcata and Codium tomentosum in a in vitro and in vivo Parkinson Disease model

  1. Silva, Joana Rita Martins da
unter der Leitung von:
  1. Rui Filipe Pinto Pedrosa Doktorvater/Doktormutter
  2. María Amparo Alfonso Rancaño Doktormutter

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 11 von November von 2021

  1. Luis Miguel Botana López Präsident
  2. Vitor Manuel Oliveira Vasconcelos Sekretär/in
  3. Jesús Gaudencio Aquino Martínez Vocal
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Art: Dissertation


The main objective of this thesis was to study the chemical profile of the algae Bifurcaria bifurcata and Codium tomentosum collected on the coast of Peniche (Portugal), evaluating the antioxidant, neuroprotective and anti-inflammatory activities of its main metabolites in an in vitro model of Parkinson's disease induced by the neurotoxin 6-hydroxydopamine on SH-SY5Y cells. This study allowed to identify 6 compounds, in which only 2 (eleganolone and loliolide) demonstrated to have neuroprotective and antiinflammatory potential. The results obtained in this work consisted of an initial approach in relation to the neuroprotective potential in a model of Parkinson's disease, allowing these compounds can studied in more complex models and to be used as pharmacological agents in the treatment of Parkinson's disease.