Learning from yeastsintracellular sensing of stress conditions

  1. Mariano José Gacto Fernández 1
  2. Teresa Soto Pino 1
  3. María Jerónima Vicente Soler 1
  4. Tomás González Villa 2
  5. José Cansado Vizoso 1
  1. 1 Universidad de Murcia

    Universidad de Murcia

    Murcia, España

    ROR https://ror.org/03p3aeb86

  2. 2 Universidade de Santiago de Compostela

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

International microbiology: official journal of the Spanish Society for Microbiology

ISSN: 1618-1905

Ano de publicación: 2003

Volume: 6

Número: 3

Páxinas: 211-219

Tipo: Artigo

DOI: 10.1007/S10123-003-0136-X DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: International microbiology: official journal of the Spanish Society for Microbiology


Citas recibidas

  • Citas en Scopus: 27 (03-03-2023)
  • Citas en Web of Science: 27 (22-03-2023)

SCImago Journal Rank

  • Ano 2003
  • Impacto SJR da revista: 0.391
  • Cuartil maior: Q2
  • Área: Microbiology (medical) Cuartil: Q2 Posición na área: 42/100
  • Área: Microbiology Cuartil: Q3 Posición na área: 70/109


One intriguing challenge in modern biology is to understand how cells respond to, and distinguish between different stressing stimuli. Evidence accumulated in recent years indicates that a network of signaling pathways extends from the plasma membrane to the very core of the cell nucleus to transduce environmental changes into a graded transcriptional response. Although many steps still remain unclear, studies on the stress-activated protein kinase (SAPK) pathways and related mechanisms provide insight into the biochemistry that regulates signal transmission and leads to outcomes such as cell adaptation and differentiation. This review focuses on selected topics of current interest related to the sensing of stress signals in cells of the fission yeast Schizosaccharomyces pombe. Because signaling pathways appear to be evolutionarily well conserved, yeasts may be useful models to learn how higher eukaryotes sense and respond to stresses at the cellular level.