Nanotechnology for the modulation of the immune response in HIV and cancer

  1. Gómez Dacoba, Tamara
Dirixida por:
  1. María José Alonso Fernández Director
  2. José Crecente Campo Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 12 de maio de 2020

Tribunal:
  1. Mariano Esteban Rodríguez Presidente/a
  2. Noemi Stefania Csaba Secretaria
  3. Derek O'Hagan Vogal
Departamento:
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Tipo: Tese

Teseo: 627813 DIALNET lock_openMINERVA editor

Resumo

Nanotechnologies with the ability to modulate the immune system can be exploited to develop new advanced therapies. The first part of this thesis describes a potential HIV vaccine candidate consisting of nanoparticles loaded with up to three peptide antigens. Based on the good responses in terms of protection against viral infection in macaques, the quality-by-design and scaling-up production of this vaccine candidate was performed. Finally, in the context of cancer, a potential immunotherapy with the capacity to polarize tumor-associated macrophages towards anti-tumoral phenotypes was developed.