Enfermedad de Alzheimer y degeneración macular asociada a la edad

  1. H.M. Roca-Santiago
  2. J.R. Lago-Bouza
  3. J.C. Millán-Calenti
  4. F. Gómez-Ulla-Irazazábal
Revista:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Ano de publicación: 2006

Volume: 81

Número: 2

Páxinas: 73-78

Tipo: Artigo

DOI: 10.4321/S0365-66912006000200006 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Archivos de la Sociedad Española de Oftalmologia

Resumo

Objetivos: Analizar diferentes factores de riesgo implicados en la aparición de la enfermedad de Alzheimer y de la degeneración macular asociada a la edad, tratando de establecer una relación de asociación entre ambas entidades. Métodos: Sobre una muestra de 57 sujetos, de los que 33 presentan demencia (casos) y 24 no (controles) se realiza estudio analítico a fin de establecer el grado de asociación entre la enfermedad de Alzheimer (EA) y la degeneración macular asociada a la edad (DMAE). Para ello, tras realizar anamnesis a todos los sujetos, se estudia el fondo de ojo mediante cámara no midriática tipo Topcon TRV-50VT. Resultados: De acuerdo a la hipótesis de trabajo planteada, aplicada la razón de productos cruzados o de disparidad (odds ratio) se obtuvo un resultado positivo que determina relación causa efecto, ya que el porcentaje de casos con DMAE (42,4%) es superior al de controles con DMAE (25%). Por otro lado mediante la Chi cuadrado de Pearson, aunque no se establecieron diferencias significativas, los datos obtenidos muestran protección en el grupo control de acuerdo al estadístico exacto de Fisher (p=0,649). Conclusiones: Existen evidencias suficientes para pensar que la EA y la DMAE podrían tener factores etiológicos y patogénicos comunes, y aunque en nuestro estudio no hemos podido establecer la relación significativa entre ambas patologías, posiblemente en base al tamaño de la muestra o a las diferencias de edades entre ambos grupos, creemos establecida la posible asociación como para plantear un futuro trabajo que pueda confirmar estos hallazgos.

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Fonte de datos: Dialnet