Difuncionalización selectiva de sistemas insaturados mediante catálise de cobre

  1. Pérez Saavedra, Borja
Dirixida por:
  1. Carlos Saa Rodríguez Director
  2. Martin Fañanas Mastral Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 14 de outubro de 2019

Tribunal:
  1. Rosana Álvarez Rodríguez Presidente/a
  2. José Pérez Sestelo Secretario/a
  3. Fernando José López García Vogal
Departamento:
  1. Departamento de Química Orgánica

Tipo: Tese

Resumo

In this thesis, two selective multiple C–C bond functionalization strategies have been investigated. In the first part, a copper-catalysed carboarylation/cyclization of alkynyl phosphonates with diaryliodonium salts has been developed giving access to five and six membered ring cyclic enol phosphonates bearing tetrasubstituted double bonds in high yields under mild conditions. In the second part, a copper-catalysed tricomponent reaction between allenes, hydroxylamine esters and bis(pinacolato)diboron has been explored for the regio-, chemo- and diastereoselective synthesis of α- and β-aminoalkenylboronates in good yields.