Endogenous systems involved in the development of pancreatic cancerrole of the obestatin/GPR39 system
- Estévez Pérez, Lara Sofía
- Rosalía Gallego Gómez Doktormutter
- Yolanda Pazos Randulfe Co-Doktorvater/Doktormutter
- J. Enrique Domínguez Muñoz Co-Doktorvater
Universität der Verteidigung: Universidade de Santiago de Compostela
Fecha de defensa: 13 von Mai von 2019
- Francisco X Real Präsident/in
- M. Clara Alvarez Villamarin Sekretärin
- María Dolores Mayán Santos Vocal
Art: Dissertation
Zusammenfassung
Pancreatic cancer is one of the most aggressive neoplasms due to its rapid spread and late diagnosis. The objective of this thesis is to elucidate the obestatin/GPR39 potential as a therapeutic target in chronic pancreatitis and pancreatic cancer. The expression of GPR39 found in normal pancreas indicates a possible regulatory and regenerative role for the obestatin/GPR39 system in the human pancreas. Likewise, the expression found in premalignant lesions could involve this system in the pathogenesis and progression to pancreatic adenocarcinoma. In addition, this system favours proliferative, invasive and tumoral settlement processes in immortalized cancer cell lines. These facts prompted us to postulate the use of GPR39 as a marker of tumoral progression and its applicability to antagonize the fundamental mechanisms associated with the development of pancreatic cancer.