Diseño y propiedades de compuestos heterolépticos derivados de Ru(η6-p-cimeno)

Abstract

n this PhD memory , Schiff-Based with a variety of aromatic-metalated-ring substitutes ligands by one hand and coordinated 1,1-Bis(diphenylphosphine)etylene-NNucleophilic Michael Addition was explored, using as a metallic center ruthenium (II) in both studies, with a h6 p-cymene ligand. Biological studies were carried for some nucleophile additions products, with the aim of determine their worthy as an antineoplasic agents. Structural elucidation of each compound were obtained by Mass Spectroscopy, NMR-1H, 13C, DEPT-135 and, where it was necessary, 31P; and FT-IR. Additionally, in the ocasions where it was posible of obtain valid monocrystals, X-Ray Diffraction for full resolution of the structure. In some compounds, in vitro and in vivo essays were made, using a variety of cancer human cell lines for in vitro, and zebrafish experimental model for in vivo essays. Futhermore, HSA interaction of these compounds were studied. Either cyclometalated or nucleophile additions products gives a new insight into structural and reactivity of both procesures in presence of an palladium more inert metallant agent, as p-cymeneruthenium (II) is. To Whom nucleophilic additions concern, post-coordination functionalization of 1,1-Bis(Vinyldiphenylphosphine) changes either in vitro or in vivo activity from original complex, providing new opportunities to the modulation of the new metallodrug; also their interaction with target molecules as HSA.