Efecto del citrato de sildenafilo sobre las respuestas visuales corticales

  1. Francisco González 1
  2. M.S. Justo 1
  3. MA Bermúdez 1
  4. Francisco Gómez Ulla 2
  5. R. Pérez 1
  1. 1 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

  2. 2 Complexo Hospitalario Universitario de Santiago
    info

    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

Revista:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Ano de publicación: 2002

Volume: 77

Número: 5

Páxinas: 241-246

Tipo: Artigo

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Outras publicacións en: Archivos de la Sociedad Española de Oftalmologia

Resumo

Objective To study the possible effect of oral sildenafil citrate on the response of cortical visual cells to visual stimulation. Method Multiunit activity was recorded from cortical area V2 of one behaving monkey. Spatio-temporal receptive field maps were obtained by using a reverse cross correlation technique and white noise visual stimulation before and after oral administration of sildenafil citrate. Results The receptive field maps showed a reduction in response latency after administration of sildenafil citrate. Conclusions Since sildenafil citrate is an inhibitor of retinal phosphodiesterase-6, an enhancement on light sensitivity in the photoreceptors is proposed as the cause of the observed reduction in response latency (Arch Soc Esp Oftalmol 2002; 77: 241-246).

Fonte de datos: Dialnet