Alteraciones bioquímicas y su correlación clínica con el liquen plano oral

Abstract

Objectives: A study is made to assess possible slight alterations in different laboratory parameters in patients with oral lichen planus (OLP) in comparison both to normal subjects and to the different clinical presentations of the disease. The possible influence of menopause and its associated metabolic disorders in the development of OLP is also investigated. Study design: A total of 106 subjects were studied, of which 52 had OLP lesions and 54 were used as controls. The following basic biochemical parameters were determined: globulin, albumin, albumin/globulin ratio, glucose, urea, creatinine, uric acid, total cholesterol, total triglycerides, lipoprotein fractions (LDL, HDL, VLDL), liver enzymes (GOT/ALT, GPT/AST, GGT), alkaline phosphatase, cholinesterase, LDH, calcium, phosphorus, thyroid hormones (TSH, T3, T4) and sex hormones (FSH, LH, estradiol, progesterone). Results: The mean values of the different biochemical parameters were within the normal range, with the exception of glucose, which exhibited borderline values, and LDL - which exceeded the reference concentrations. Patients with OLP in turn showed higher mean cholesterol levels than the controls. Patients with atrophic-erosive OLP presented an increase in VLDL versus those patients with reticular lesions. Conclusions: The endocrine changes associated with menopause were not seen to influence the development of OLP or its clinical type. Minor alterations in lipid metabolism were observed in patients with OLP.