Hipercortisolismo de origen adrenal

  1. C. Guillín 1
  2. I. Bernabeu 1
  3. I.A. Rodríguez-Gómez 2
  4. F.F. Casanueva 1
  1. 1 Complexo Hospitalario Universitario de Santiago
    info

    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

  2. 2 Unidad de Endocrinología y Nutrición. Hospital HM Modelo. La Coruña. España
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2016

Issue Title: Enfermedades endocrinológicas y metabólicas (II) Patología suprarrenal

Series: 12

Issue: 14

Pages: 781-786

Type: Article

DOI: 10.1016/J.MED.2016.06.011 DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Introduction The Cushing's syndrome results from a chronic exposure to high levels of glucocorticoids. The most common cause of hypercortisolism is the exogenous or pharmacological one. Within the endogenous causes, they can be corticotropin-dependent (ie. pituitary origin) or independent (ie. adrenal origin). History and clinical examination Cushing's syndrome is characterized by a variable combination of symptoms affecting several organs and systems: centripetal obesity, insulin resistance, dyslipidaemia, reproductive dysfunction, skin weakness, osteoporosis and even psychiatric disorders, among others. Evaluation In patients with clinical suspicion of Cushing's syndrome, and once discarded the exogenous causes, we have to biochemically confirm the hypercortisolism, identify whether it is corticotropin dependent or independent and, finally, try locate the source of hormonal excess. Treatment The treatment of choice is surgery. Medical treatment is indicated when surgery is postponed, contraindicated or unsuccessful.

Bibliographic References

  • Kronenberg HM, Melmed S, Polonsky KS, Larsen R. Williams tratado de endocrinología. 11ª ed. Barcelona: Elsevier Saunders; 2009.
  • NiemanLK, Biller BM, FindlingJW, Newell-Price J, Savage MO, Stewart PM, et al. The diagnosis of Cushing’s syndrome: an endocrine society clinical practice guideline. J ClinEndocrinolMe-tab. 2008;93(5):1526-40.
  • Raff H. Cushing syndrome: updateontesting. Endocrinol Metab Clin N Am. 2015;44(1):43-50.
  • Terzolo M, Pia A, Reimondo G. Subclinical Cushing’s syndrome: definition and management. ClinEndocrinol (Oxf). 2012;76(1):12-8.
Data source: Dialnet