Tendinopatía del tendón flexor digital superficial y desmopatía del ligamento suspensorio en caballosfisiopatología y terapias regenerativas

  1. JU Carmona
  2. C López
Zeitschrift:
Archivos de Medicina Veterinaria

ISSN: 0301-732X,  0717-6201

Datum der Publikation: 2011

Ausgabe: 43

Nummer: 3

Seiten: 203-214

Art: Artikel

DOI: 10.4067/S0301-732X2011000300002 DIALNET GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: Archivos de Medicina Veterinaria

Ziele für nachhaltige Entwicklung

Zusammenfassung

Las lesiones de tendones y ligamentos son frecuentes en caballos. Las estructuras más afectadas son el tendón digital flexor superficial (SDFT) y el ligamento suspensor (LS). La forma clínica de estas patologías generalmente es crónica y de naturaleza degenerativa. Los tratamientos comúnmente empleados no producen curación definitiva del problema. Una gran mayoría de pacientes recaen o no vuelven a recuperar su capacidad atlética inicial. El avance del conocimiento molecular de la fisiopatología de las tendinopatías y desmopatías del hombre, caballo y otros animales ha permitido evidenciar la presencia de citocinas catabólicas, las cuales posiblemente sean responsables del trastorno general observado en estas patologías. El objetivo actual del tratamiento de estos problemas es la regeneración y no la reparación (cicatriz) del tejido lesionado. En el caballo se han descrito tratamientos experimentales y clínicos novedosos. Estos tratamientos incluyen la inyección de aspirados de médula ósea, células madre mesenquimales, factores de crecimiento recombinantes como el factor de crecimiento insulínico tipo I y plasma rico en plaquetas (también llamado concentrado autólogo de plaquetas), entre otros. Los resultados observados han sido prometedores cuando estas novedosas terapias han sido empleadas. Sin embargo, al igual que lo que sucede con otros tratamientos, es necesario realizar más investigaciones para demostrar que su uso clínico puede ser efectivo y seguro en caballos.

Bibliographische Referenzen

  • Abellanet, I. (2009). La terapia de lesiones de tejidos blandos y articulaciones con plasma rico en plaquetas en caballos de deporte: evidencia clínica y bioquímica que valida su utilización.
  • Abramowitch, SD, Yagi, M, Tsuda, E, Woo, SLY. (2003). The healing medial collateral ligament following a combined anterior cruciate and medial collateral ligament injury-a biomechanical study in a goat model. J Orthop Res. 21. 1124-1130
  • Anderson, TM, McIlwraith, CW, Douay, P. (2004). The role of conformation in musculoskeletal problems in the racing Thoroughbred. Equine Vet J. 36. 571-575
  • Anitua, E, Andia, I, Ardanza, B, Nurden, P, Nurden, AT. (2004). Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 91. 4-15
  • Anitua, E, Andia, I, Sanchez, M, Azofra, J, Zalduendo, MM, de la Fuente, M, Nurden, P, Nurden, A. (2005). Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthoph Res. 23. 281-286
  • Arai, K, Kasashima, Y, Kobayashi, A, Kuwano, A, Yoshihara, T. (2002). TGF-[β] alters collagen XII and XIV mRNA levels in cultured equine tenocytes. Matrix Biol. 21. 243-250
  • Argüelles, D, Carmona, JU, Pastor, J, Iborra, A, Viñals, L, Martínez, P, Bach, E, Prades, M. (2006). Evaluation of single and double centrifugation tube methods for concentrating equine platelets. Res Vet Sci. 81. 237-245
  • Birch, HL, Bailey, JVB, Bailey, AJ, Goodship, AE. (1999). Age-related changes to the molecular and cellular components of equine flexor tendons. Equine Vet J. 31. 391-396
  • Birch, HL, Wilson, AM, Goodship, AE. (2008). Physical activity: does long-term, high-intensity exercise in horses result in tendon degeneration?. J Appl Physiol. 105. 1927-1933
  • Bosch, G, Moleman, M, Barneveld, A, Van Weeren, PR, Van Schie, HTM. (2010). The effect of platelet-rich plasma on the neovascularization of surgically created equine superficial digital flexor tendon lesions. Scand J Med Sci Sports.
  • Brockes, JP, Kumar, A. (2008). Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol. 24. 525-549
  • Carmona, JU, Prades, M. (2009). Pathophysiology of osteoarthritis. Com Equine. 4. 28-40
  • Carmona, J, Prades, M, Argüelles, D. (2009). Concentrados autólogos de plaquetas como tratamiento de lesiones de tejidos blandos del aparato locomotor en caballos. Arch Med Vet. 41. 77-82
  • Carmona, JU, López, C, Giraldo, CE. (2011). Uso de concentrados autólogos de plaquetas como terapia regenerativa de enfermedades crónicas del aparato músculo-esquelético equino. Arch Med Vet. 43. 1-10
  • Carter, CA, Jolly, DG, Worden, CE, Hendren, DG, Kane, CJM. (2003). Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol. 74. 244-255
  • Chang, HJ, Burke, AE, Glass, RM. (2010). Achilles tendinopathy. J Am Vet Med Assoc. 303. 188
  • Crevier-Denoix, N, Collobert, C, Pourcelot, P, Denoix, J, Sanaa, M, Geiger, D, Bernard, N, Ribot, X, Bortolussi, C, Bousseau, B. (1997). Mechanical properties of pathological equine superficial digital flexor tendons. Equine Vet J. 29. 23-26
  • Crovace, A, Lacitignola, L, Giacomo, R, Edda, F. (2010). Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon. Vet Med Int.
  • Dahlgren, LA, Nixon, AJ, Brower-Toland, BD. (2001). Effects of β-aminopropionitrile on equine tendon metabolism in vitro and on effects of insulin-like growth factor-I on matrix production by equine tenocytes. Am J Vet Res. 62. 1557-1562
  • Dahlgren, LA, van der Meulen, MCH, Bertram, JEA, Starrak, GS, Nixon, AJ. (2002). Insulin-like growth factor-I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis. J Orthop Res. 20. 910-919
  • Dahlgren, LA. (2007). Pathobiology of tendon and ligament injuries. Clin Tech Equine Pract. 6. 168-173
  • Dart, AJ, Little, CB, Hughes, CE, Chu, Q, Dowling, BA, Hodgson, DR, Rose, RJ, Johnson, KA. (2003). Recombinant equine growth hormone administration: effects on synovial fluid biomarkers and cartilage metabolism in horses. Equine Vet J. 35. 302-307
  • Denoix, J. (1994). Functional anatomy of tendons and ligaments in the distal limbs (manus and pes). Vet Clin North Am Equine Pract. 10. 273-322
  • Dowling, BA, Dart, AJ, Hodgson, DR, Smith, RKW. (2000). Superficial digital flexor tendonitis in the horse. Equine Vet J. 32. 369-378
  • Dowling, BA, Dart, AJ, Hodgson, DR, Rose, RJ, Walsh, WR. (2002). The effect of recombinant equine growth hormone on the biomechanical properties of healing superficial digital flexor tendons in horses. Vet Surg. 31. 320-324
  • Dowling, BA, Dart, AJ. (2005). Mechanical and functional properties of the equine superficial digital flexor tendon. Vet J. 170. 184-192
  • Dyson, S, Arthur, R, Palmer, S, Richardson, D. (1995). Suspensory ligament desmitis. Vet Clin North Am Equine Pract. 11. 177-215
  • Dyson, S, Genovese, R. (2003). Diagnosis and management of lameness in the horse. WB Saunders. St Louis. 654-666
  • Dyson, SJ. (2004). Medical management of superficial digital flexor tendonitis: a comparative study in 219 horses (1992-2000). Equine Vet J. 36. 415-419
  • Edwards, LJ, Goodship, AE, Birch, HL, Patterson-Kane, JC. (2005). Effect of exercise on age-related changes in collagen fibril diameter distributions in the common digital extensor tendons of young horses. Am J Vet Res. 66. 564-568
  • Gaujoux-Viala, C, Dougados, M, Gossec, L. (2009). Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomised controlled trials. Ann Rheum Dis. 68. 1843-1849
  • Goodship, A, Birch, H, Wilson, A. (1994). The pathobiology and repair of tendon and ligament injury. Vet Clin North Am Equine Pract. 10. 323-349
  • Guest, DJ, Smith, MRW, Allen, WR. (2010). Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendon. Equine Vet J. 42. 636-642
  • Gurtner, GC, Callaghan, MJ, Longaker, MT. (2007). Progress and potential for regenerative medicine. Annu Rev Med. 58. 299-312
  • Halper, J, Kim, B, Khan, A, Yoon, J, Mueller, P. (2006). Degenerative suspensory ligament desmitis as a systemic disorder characterized by proteoglycan accumulation. BMC Vet Res. 2. 12
  • Henninger, R. (1994). Treatment of superficial digital flexor tendinitis. Vet Clin North Am Equine Pract. 10. 409-424
  • Herthel, DJ. (2001). Enhanced suspensory ligament healing in 100 horses by stem cells and other bone marrow components. Lameness in the athletic horse: Proceedings. Annual Convention of the AAEP.319-321
  • Hosaka, Y, Kirisawa, R, Yamamoto, E, Ueda, H, Iwai, H, Takehana, K. (2002). Localization of cytokines in tendinocytes of the superficial digital flexor tendon in the horse. J Vet Med Sci. 64. 945-947
  • Kaneps, AJ. (2007). Surgical options for treating tendon and ligament injuries. Clin Tech Equine Pract. 6. 209-216
  • Kastelic, J, Galeski, A, Baer, E. (1978). The multicomposite structure of tendon. Connect Tissue Res. 6. 11-23
  • Kobayashi, A, Sugisaka, M, Takehana, K, Yamaguchi, M, Iwasa, EK, Abe, M. (1999). Morphological and histochemical analysis of a case of superficial digital flexor tendon injury in the horse. J Comp Pathol. 120. 403-414
  • Maia, L, de Souza, MV, Ribeiro, JI, de Oliveira, AC, Alves, GES, Benjamin, LD, Silva, Y, Zandim, BM, Moreira, JDL. (2009). Platelet-rich plasma in the treatment of induced tendinopathy in horses: histologic evaluation. J Equine Vet Sci. 29. 618-626
  • Marx, RE. (2004). Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 62. 489-496
  • McCarrel, T, Fortier, L. (2009). Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res. 27. 1033-1042
  • Murray, MM, Rice, K, Wright, RJ, Spector, M. (2003). The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three-dimensional collagen-GAG scaffold. J Orthop Res. 21. 238-244
  • Nam, H, Park, Y, Yoon, G, Cho, H, Lee, J. (2010). Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation. Exp Mol Med. 42. 270-279
  • Nixon, A, Brower-Toland, B, Sandell, L. (1999). Primary nucleotide structure of predominant and alternate splice forms of equine insulinlike growth factor I and their gene expression patterns in tissues. Am J Vet Res. 60. 1234-1241
  • Paavola, M, Kannus, P, Jarvinen, TAH, Khan, K, Józsa, L, Jarvinen, M. (2002). Achilles tendinopathy. J Bone Joint Surg Am. 84. 2062-2076
  • Patterson-Kane, JC, Parry, DA, Birch, HL, Goodship, AE, Firth, EC. (1997). An age-related study of morphology and cross-link composition of collagen fibrils in the digital flexor tendons of young thoroughbred horses. Connect Tissue Res. 36. 253-260
  • Patterson-Kane, J, Wilson, A, Firth, E, Parry, D, Goodship, A. (1998). Exercise-related alterations in crimp morphology in the central regions of superficial digital flexor tendons from young thoroughbreds: a controlled study. Equine Vet J. 30. 61-64
  • Pauwels, FE, Schumacher, J, Mayhew, IG, van Sickle, DC. (2009). Neurectomy of the deep branch of the lateral plantar nerve can cause neurogenic atrophy of the muscle fibres in the proximal part of the suspensory ligament (M. interosseous III). Equine Vet J. 41. 508-510
  • Peters-Veluthamaningal, C, van der Windt, D, Winters, J, dJ B, M. (2009). Corticosteroid injection for de Quervain's tenosynovitis. Cochrane Database Syst Rev. 8.
  • Platt, D, Bird, JLE, Bayliss, MT. (1998). Ageing of equine articular cartilage: structure and composition of aggrecan and decorin. Equine Vet J. 30. 43-52
  • Pool, R, Meagher, D. (1990). Pathologic findings and pathogenesis of racetrack injuries. Vet Clin North Am Equine Pract. 6. 1-30
  • Ross, M, Dyson, S. (2002). Diagnosis and management of lameness in the horse. Saunders. Philadelphia. 73
  • Sánchez, M, Azofra, J, Anitua, E, Andía, I, Padilla, S, Santisteban, J, Mujika, I. (2003). Plasma rich in growth factors to treat an articular cartilage avulsion: A case report. Med Sci Sports Exerc. 35. 1648-1652
  • Sánchez, M, Anitua, E, Azofra, J, Andía, I, Padilla, S, Mujika, I. (2007). Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 35. 245-251
  • Schnabel, LV, Mohammed, HO, Miller, BJ, McDermott, WG, Jacobson, MS, Santangelo, KS, Fortier, LA. (2007). Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res. 25. 230-240
  • Schnabel, LV, Mohammed, HO, Jacobson, MS, Fortier, LA. (2008). Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures. Equine Vet J. 40. 260-265
  • Schnabel, LV, Lynch, ME, van der Meulen, MC, Yeager, AE, Kornatowski, MA, Nixon, AJ. (2009). Mesenchymal stem cells and insulinlike growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons. J Orthop Res. 27. 1392-1398
  • Smith, RK, Birch, H, Patterson-Kane, J, Firth, EC, Williams, L, Cherdchutham, W, Weeren, WR, Goodship, AE. (1999). Should equine athletes commence training during skeletal development?: changes in tendon matrix associated with development, ageing, function and exercise. Equine Vet J. 31. 201-209
  • Smith, RKW, Gerard, M, Dowling, B, Dart, AJ, Birch, HL, Goodship, AE. (2002). Correlation of cartilage oligomeric matrix protein (COMP) levels in equine tendon with mechanical properties: a proposed role for COMP in determining function-specific mechanical characteristics of locomotor tendons. Equine Vet J. 34. 241-244
  • Smith, R, Schramme, M. (2003). Tendon injury in the horse: current theories and therapies. In Pract. 25. 529-539
  • Smith, RKW, Korda, M, Blunn, GW, Goodship, AE. (2003). Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment. Equine Vet J. 35. 99-102
  • Smith, JJ, Ross, MW, Smith, RK. (2006). Anabolic effects of acellular bone marrow, platelet rich plasma, and serum on equine suspensory ligament fibroblasts in vitro. Vet Comp Orthop Traumatol. 19. 43-47
  • Smith, RKW. (2008). Mesenchymal stem cell therapy for equine tendinopathy. Disabil Rehabil. 30. 1752-1758
  • Souza, MV, Van Weeren, PR, Van Schie, HTM, Van De Lest, CHA. (2010). Regional differences in biochemical, biomechanical and histomorphological characteristics of the equine suspensory ligament. Equine Vet J. 42. 611-620
  • Spindler, KP, Murray, MM, Detwiler, KB, Tarter, JT, Dawson, JM, Nanney, LB, Davidson, JM. (2003). The biomechanical response to doses of TGF-β2 in the healing rabbit medial collateral ligament. J Orthop Res. 21. 245-249
  • Sutter, WW, Kaneps, AJ, Bertone, AL. (2004). Comparison of hematologic values and transforming growth factor-β and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. Am J Vet Res. 65. 924-930
  • Tang, JB, Xu, Y, Ding, F, Wang, XT. (2003). Tendon healing in vitro: promotion of collagen gene expression by bFGF with NF-kappaB gene activation. J Hand Surg Am. 28. 215-220
  • Thorpe, CT, Clegg, PD, Birch, HL. (2010). A review of tendon injury: Why is the equine superficial digital flexor tendon most at risk?. Equine Vet J. 42. 174-180
  • Van Miert, ASJPAM. (2002). Present concepts on the inflammatory modulators with special reference to cytokines. Vet Res Commun. 26. 111-126
  • Verwilghen, D, Vanderheyden, L, Franck, T, Busoni, V, Enzerink, E, Gangl, M, Lejeune, JP, van Galen, G, Grulke, S, Serteyn, D. (2009). Variations of plasmatic concentrations of insulin-like growth factor-I in post-pubescent horses affected with developmental osteochondral lesions. Vet Res Commun. 33. 701-709
  • Waselau, M, Sutter, WW, Genovese, RL, Bertone, AL. (2008). Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses. J Am Vet Med Assoc. 232. 1515-1520
  • Wong, MWN, Tang, YYN, Lee, SKM, Fu, BSC, Chan, BP, Chan, CKM. (2003). Effect of dexamethasone on cultured human tenocytes and its reversibility by platelet-derived growth factor. J Bone Joint Surg Am. 85. 1914-1920
  • Woo, SLY, Almarza, AJ, Karaoglu, S, Abramowitch, SD. (2008). Principles of Regenerative Medicine. Academic Press. San Diego. 1206-1231
  • Woo, SLY, Fisher, MB, Feola, AJ. (2008). Contribution of biomechanics to management of ligament and tendon injuries. Mol Cell Biomech. 5. 49-68
  • Zhang, F, Liu, H, Stile, F, Lei, M-P, Pang, Y, Oswald, TM, Beck, J, Dorsett-Martin, W, Lineaweaver, WC. (2003). Effect of vascular endothelial growth factor on rat Achilles tendon healing. Ann Plast Surg. 112. 1613-1619
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