Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru

  1. Flores, Claudio
  2. Rodríguez Girondo, Mar
  3. Cadarso Suárez, Carmen María
  4. Gómez Melis, Guadalupe
  5. Casanova, Luis
  6. Kneib, Thomas
Zeitschrift:
Sort: Statistics and Operations Research Transactions

ISSN: 1696-2281

Datum der Publikation: 2012

Ausgabe: 36

Nummer: 2

Seiten: 221-230

Art: Artikel

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Andere Publikationen in: Sort: Statistics and Operations Research Transactions

Zusammenfassung

Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type structured hazard regression models while accounting for potential spatial correlations in the survival times. We identified eight covariates with significant effect for overall survival. Some of them are widely known such as age, performance status, clinical stage and lactic dehydrogenase, but we also identified hemoglobin, leukocytes and lymphocytes as covariates with a significant effect on the overall survival of patients with NHL. Besides, the effect of continuous covariates is clearly nonlinear and hence impossible to detect with the classical Cox method. Although the spatial component does not show a significant effect, the results show a trend of low risk in certain areas.

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