Estudio de los efectos biológicos de biomoléculas de origen marino sobre cultivos de células humanas y modelos animales de enfermedades human

  1. María Roel Sánchez
Dirixida por:
  1. Luis Miguel Botana López Director
  2. Juan Andrés Rubiolo Gaytán Director

Universidade de defensa: Universidade de Santiago de Compostela

Ano de defensa: 2018

Tribunal:
  1. Juan Ignacio Ramos Martínez Presidente
  2. Eva Mª Cagide Otero Secretario/a
  3. Ralph Urbatzka Vogal
Departamento:
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Tipo: Tese

Resumo

The dissertation entitled “Biological effects of marine compounds on human cells and animal models of human diseases” deals with the in depth study of the biological effects of several guanidine alkaloids originally isolated from the marine sponge Crambe crambe known as crambescins and crambescidins. Crambescidins constitute a large family of secondary metabolites with an interesting antitumoral activity against several types of human tumors. Herein we characterize the underlying cellular mechanisms and the involved signaling networks. Furthermore, the present work describes their activities on cell-cell adhesion, cell-matrix adhesion and cell cytoskeleton, also confirming their efficacy and capacity to impair the growth and to induce tumor regression in vivo. The biological effects of several crambescins analogs have been assayed and the results of the studies carried out towards that objective are also presented in this dissertation, demonstrating their cytoprotective effect against oxidative injury through metallothionein induction. These results support the pharmacological utility of marine natural molecules and their value as lead compounds for the synthesis and optimization of new chemical structures.