The sea lamprey GABAB receptorChanges after spinal cord injury and its role in axonal regeneration

  1. Romaus Sanjurjo, Daniel
unter der Leitung von:
  1. María Celina Rodicio Doktormutter
  2. Antón Barreiro Iglesias Co-Doktorvater

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 20 von April von 2018

Gericht:
  1. Ramon Anadon Vazquez Präsident
  2. Idoia Quintana Urzainqui Sekretär/in
  3. Arsenio Fernández López Vocal
Fachbereiche:
  1. Departamento de Bioloxía Funcional

Art: Dissertation

Teseo: 549817 DIALNET lock_openMINERVA editor

Zusammenfassung

Spinal cord injury (SCI) causes irreversible loss of function. In contrast to mammals, lampreys show an amazing capacity for spontaneous recovery after a complete SCI. In this study, we analysed the changes in the expression of both gabab subunits after a complete SCI. Our results showed that plastic changes in this system probably contribute to the recovery of function after SCI in lampreys. Pharmacological and genetic manipulations revealed that GABA acting through GABAB receptors promotes axonal regeneration of descending neurons after a complete SCI in lampreys.