New strategies for cardiac repair using polymer-based drug delivery systems loaded with growth factors
- Pascual Gil de Gómez, Simón
- María José Blanco Prieto Director
- Felipe Prósper Cardoso Co-director
Universidade de defensa: Universidad de Navarra
Fecha de defensa: 25 de xuño de 2018
- José Antonio Páramo Fernández Presidente/a
- Josune Orbe Secretario/a
- Ana Colette Pereira de Castro Osorio Mauricio Vogal
- Gorka Orive Arroyo Vogal
- Mariana Landín Pérez Vogal
Tipo: Tese
Resumo
Myocardial infarction (MI) is the main cardiovascular disease, causing more than 7 million deaths per year 1. In spite of its clinical relevance 2,3, this pathology is from been controlled and risk factors associated to it are considerably augmenting in modern society, as pointed out by the World Health Organization, which has estimated that the number of MI events will dramatically increase by 2030 1. MI is usually started by the occlusion of a coronary artery, that causes an ischemic condition in the cardiac tissue. This lack of oxygen supply induces a massive cell death of cardiac cells and a negative tissue remodeling takes place. Consequently, functional limitations and eventually death may occur.