Publicacións (23) Publicacións nas que participase algún/ha investigador/a

filter_list Drug Discovery

2024

  1. Dynamic Covalent Boronate Chemistry Accelerates the Screening of Polymeric Gene Delivery Vectors via In Situ Complexation of Nucleic Acids

    Journal of the American Chemical Society, Vol. 146, Núm. 25, pp. 17211-17219

2023

  1. β-Peptides incorporating polyhydroxylated cyclohexane β-amino acid: synthesis and conformational study

    Organic and Biomolecular Chemistry, Vol. 21, Núm. 42, pp. 8535-8547

2022

  1. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1Antagonists

    Journal of Medicinal Chemistry, Vol. 65, Núm. 3, pp. 2091-2106

  2. Polyhydroxylated Cyclopentane β-Amino Acids Derived from d -Mannose and d -Galactose: Synthesis and Protocol for Incorporation into Peptides

    ACS Omega, Vol. 7, Núm. 2, pp. 2002-2014

2020

  1. New morphiceptin peptidomimetic incorporating (1S,2R,3S,4S,5R)-2-amino-3,4,5-trihydroxycyclopentane-1-carboxylic acid: Synthesis and structural study

    Molecules, Vol. 25, Núm. 11

2019

  1. Chain-Branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases

    Pharmaceuticals, Vol. 12, Núm. 2

2017

  1. Synthesis of spironucleosides: Past and future perspectives

    Molecules, Vol. 22, Núm. 11

2014

  1. GATG dendrimers and PEGylated block copolymers: From synthesis to bioapplications

    AAPS Journal, Vol. 16, Núm. 5, pp. 948-961

2012

  1. Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D 3 analogues with a long side chain at C12 and short C17 side chains

    Journal of Medicinal Chemistry, Vol. 55, Núm. 20, pp. 8642-8656

  2. Synthesis of (1α)-1,25-dihydroxyvitamin D 3 with a β-positioned seven-carbon side chain at C(12)

    Helvetica Chimica Acta, Vol. 95, Núm. 10, pp. 1842-1850

2011

  1. On a possible neutral charge state for the catalytic dyad in β-secretase when bound to hydroxyethylene transition state analogue inhibitors

    Journal of Medicinal Chemistry, Vol. 54, Núm. 8, pp. 3081-3085

  2. Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D 3 analogues hydroxymethylated at C-26

    Journal of Medicinal Chemistry, Vol. 54, Núm. 11, pp. 3950-3962

2010

  1. Structure-function relationships and crystal structures of the vitamin D receptor bound 2α-methyl-(20S,23S)- and 2α-methyl-(20S,23R)- epoxymethano-1α,25-dihydroxyvitamin D3

    Journal of Medicinal Chemistry, Vol. 53, Núm. 3, pp. 1159-1171

2008

  1. Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation

    Journal of Medicinal Chemistry, Vol. 51, Núm. 4, pp. 852-860

2007

  1. Total synthesis of (5S,6S)-6-amino-2,8-dimethylnonan-5-ol and (5S,6S)-6-amino-7-cyclohexyl-2-methylheptan-5-ol

    Arkivoc, Vol. 2007, Núm. 4, pp. 380-388

2006

  1. Antiplasmodial metabolites isolated from the marine octocoral Muricea austera

    Journal of Natural Products, Vol. 69, Núm. 10, pp. 1379-1383

  2. Novel 1α,25-dihydroxyvitamin D3 analogues with the side chain at C12

    Journal of Medicinal Chemistry, Vol. 49, Núm. 5, pp. 1509-1516

2005

  1. Leptolide, a new furanocembranolide diterpene from Leptogorgia alba

    Journal of Natural Products, Vol. 68, Núm. 4, pp. 614-616

2000

  1. Hemolytic polar steroidal constituents of the starfish Aphelasterias japonica

    Journal of Natural Products, Vol. 63, Núm. 8, pp. 1178-1181

  2. Triterpene glycosides from the Far-Eastern sea cucumber Pentamera calcigera. 1. Monosulfated glycosides and cytotoxicity of their unsulfated derivatives

    Journal of Natural Products, Vol. 63, Núm. 1, pp. 65-71