Desinfarma

Descubrimento e síntese de fármacos

Detalle Liñas de investigación Oferta científica Proxectos Publicacións Colaboración Teses Patentes

Publicacións (7) Publicacións nas que participase algún/ha investigador/a

Internal Medicine

2024

Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
Biomedicine and Pharmacotherapy, Vol. 173

2023

Exploring the Effect of Halogenation in a Series of Potent and Selective A2BAdenosine Receptor Antagonists
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 890-912

2022

A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Journal for ImmunoTherapy of Cancer, Vol. 10, Núm. 5
Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands
Biomedicine and Pharmacotherapy, Vol. 153

2021

3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480

2017

Review of theoretical models to study natural products with antiprotozoal activity
Current Drug Targets, Vol. 18, Núm. 5, pp. 605-616

2016

Model for classification of a ChEMBL dataset of anti-breast cancer-compounds conforming to multiple pharmacological parameters, biological assays, and receptors
Letters in Drug Design and Discovery, Vol. 13, pp. 491-496