Desinfarma
Descubrimento e síntese de fármacos
Publicacións (18) Publicacións nas que participase algún/ha investigador/a
2022
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Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3Antagonists
ACS Medicinal Chemistry Letters, Vol. 13, Núm. 2, pp. 243-249
2013
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Discovery of 3,4-dihydropyrimidin-2(1 H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists
ACS Medicinal Chemistry Letters, Vol. 4, Núm. 11, pp. 1031-1036
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Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
European Journal of Medicinal Chemistry, Vol. 59, pp. 235-242
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The origin of stereoselectivity in cycloaddition reactions promoted by stereoisomers of 8-phenylmenthyl glyoxylate oxime
Tetrahedron, Vol. 69, Núm. 24, pp. 5048-5057
2011
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Supported p-toluenesulfonic acid as a highly robust and eco-friendly isocyanide scavenger
ACS Combinatorial Science, Vol. 13, Núm. 1, pp. 89-95
2010
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Synthesis of methyl (±)-3,5-bis(substitutedmethyl)pyrrolidine-2- carboxylates: A convenient approach to proline-mimetics
Tetrahedron, Vol. 66, Núm. 34, pp. 6797-6805
2009
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1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships
Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 10, pp. 3618-3629
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Stereocontrolled transformation of nitrohexofuranoses into cyclopentylamines via 2-oxabicyclo[2.2.1]heptanes. IV: Synthesis of enantiopure methyl (1S,2R,3R,4R,5S)-5-benzyloxycarbonylamino-2,3-isopropylidenedioxy-4-methoxycyclopentanecarboxylate
Tetrahedron Asymmetry, Vol. 20, Núm. 6-8, pp. 892-896
2008
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Stereocontrolled transformation of nitrohexofuranoses into cyclopentylamines via 2-oxabicyclo[2.2.1]heptanes. III: synthesis of enantiopure methyl (1S,2S,3R,4S,5R)-2-amino-3,4,5-trihydroxycyclopentanecarboxylate
Tetrahedron Asymmetry, Vol. 19, Núm. 24, pp. 2907-2912
2007
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A novel approach to the synthesis of benzo[b]fluoren-11-ones
Tetrahedron Letters, Vol. 48, Núm. 12, pp. 2147-2149
2006
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Stereoselective synthesis of polyhydroxylated pyrrolidines: a route to novel 3,5-bis(hydroxymethyl)pyrrolidines from 2-azabicyclo[2.2.1]hept-5-enes
Tetrahedron Letters, Vol. 47, Núm. 43, pp. 7595-7597
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Synthesis of two precursors of heterocarbocyclic nucleoside analogues
European Journal of Organic Chemistry, pp. 759-764
2005
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Experimental and DFT study of the aza-Diels-Alder reaction between cyclopentadiene and protonated benzylimine derivated from glyoxylates
Tetrahedron, Vol. 61, Núm. 46, pp. 10951-10957
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Synthesis of enantiopure cyclobutane amino acids and amino alcohols
Tetrahedron Asymmetry, Vol. 16, Núm. 15, pp. 2593-2597
2004
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Synthesis of new 6-substituted purinyl-5′-nor-1′- homocarbanucleosides based on indanol
Tetrahedron, Vol. 60, Núm. 41, pp. 9245-9253
2003
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The exo-selectivity of the new non-natural chiral auxiliary (+)-(1R,endo)-2-benzonorbornenol in an asymmetric aza-Diels-Alder reaction
Tetrahedron Letters, Vol. 44, Núm. 3, pp. 431-433
2002
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Synthetic approaches to (±)-c-4-amino-r-1,c-2,t-3-cyclopentanetrimethanol: A precursor of higher homologues of xylo-carbocyclic nucleosides
Tetrahedron, Vol. 58, Núm. 5, pp. 967-974
2000
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A short, efficient synthesis of the chiral auxiliary (+)-8- phenylneomenthol
Tetrahedron Letters, Vol. 41, Núm. 21, pp. 4123-4125