Design and biopharmaceutical preclinical characterisation of a new thermosensitive hydrogel for the removal of gastric polyps

  1. Varela-Rey, Iria 234
  2. de la Iglesia, Daniel 1
  3. San Bruno-Ruz, Alba 1
  4. Mejuto-Fernández, Rafael 1
  5. Monteserín-Ron, Luzdivina 1
  6. López-Diaz, Javier 1
  7. García-Salom, Pedro 5
  8. González-Cantalapiedra, Antonio 7
  9. Brea, Jose Manuel 6
  10. Piña-Márquez, Rocío 6
  11. Díaz-Tomé, Victoria 4
  12. González-Barcia, Miguel 23
  13. Zarra-Ferro, Irene 23
  14. Mondelo-García, Cristina 23
  15. Dominguez-Muñoz, J Enrique 1
  16. Otero-Espinar, Francisco J 4
  17. Fernández-Ferreiro, Anxo 23
  1. 1 Digestive Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, Spain
  2. 2 Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, Spain
  3. 3 Clinical Pharmacology Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain
  4. 4 Pharmacology, Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), 15782
  5. 5 Pharmacy Department, University Clinical Hospital Dr. Balmis, 03010 Alicante, Spain
  6. 6 Biofarma Group, CIMUS, 15706 Santiago de Compostela, Spain
  7. 7 Rof Codina Veterinary Hospital, Lugo, Spain
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Journal:
International Journal of Pharmaceutics

ISSN: 0378-5173

Year of publication: 2023

Volume: 635

Pages: 122706

Type: Article

DOI: 10.1016/J.IJPHARM.2023.122706 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: International Journal of Pharmaceutics

Abstract

Submucosal injection agents are widely used solutions in gastric polyp resection techniques. Currently, many different solutions are used in clinical practice, but most are not authorised for this use or are not biopharmaceutical characterised. The objective of this multidisciplinary work is to test the efficacy of a novel thermosensitive hydrogel designed specifically for this indication.

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