Advances in Drug Delivery Strategies for Microbial Healthcare Products

  1. Ageitos, Jose Manuel 1
  2. Garcia-Fuentes, Marcos 1
  1. 1 Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) and Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain
Environmental Chemistry for a Sustainable World

ISSN: 2213-7114

ISBN: 9783030018801

Year of publication: 2019

Pages: 1-38

Type: Book chapter

DOI: 10.1007/978-3-030-01881-8_1 GOOGLE SCHOLAR lock_openOpen access editor


Cited by

  • Web of Science Cited by: 2 (23-09-2023)
  • Dimensions Cited by: 3 (23-03-2023)


(Data updated as of 23-03-2023)
  • Total citations: 3
  • Recent citations: 1
  • Field Citation Ratio (FCR): 0.47


In wound healing, gene therapy strategies have the largest potential as new treatments for refractory chronic wounds. This potential of gene therapy stems from its capacity to regulate genes that reverse the key hallmarks driving chronic wound formation: inflammation, reduced angiogenesis, and impaired re-epithelization. Indeed, the most important strategies followed with gene therapy have been signalling supplementation and the inhibition of critical pathways that are dysregulated in chronic wounds. Gene therapies in wound healing can be delivered either by a systemic administration route or, more commonly, by local administration. The chapter briefly discusses a specific delivery platform of particular interest in tissue regeneration and wound healing referred to as a gene-activated matrix. The results from the clinical trials analysed to date have confirmed the safety of gene therapy strategies in chronic wound management but present an uncertain landscape regarding efficacy.

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