Survival study of leukoplakia malignant transformation in a region of northern Spain

  1. Pilar Gándara Vila 1
  2. Mario Pérez-Sayáns 2
  3. José Manuel Suárez Peñaranda 3
  4. M. Mercedes Gallas Torreira 1
  5. José Manuel Somoza Martín 1
  6. Dolores Reboiras López 1
  7. Andrés Blanco Carrión 1
  8. Abel García García 2
  1. 1 PhD, DDS. Oral Medicine, Oral Surgery and Implantology Unit. Faculty of Medicine and Dentistry, Santiago de Compostela, Spain
  2. 2 Instituto de Investigación Sanitaria de Santiago de Compostela

    Instituto de Investigación Sanitaria de Santiago de Compostela

    Santiago de Compostela, España

  3. 3 MD, PhD. Department of Pathology and Forensic Sciences. University Hospital and School of Medicine of Santiago de Compostela
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Ano de publicación: 2018

Volume: 23

Número: 4

Páxinas: 6

Tipo: Artigo

DOI: 10.4317/MEDORAL.22326 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa


Citas recibidas

  • Citas en Scopus: 28 (16-09-2023)
  • Citas en Web of Science: 24 (21-09-2023)
  • Citas en Dimensions: 28 (31-03-2023)

JCR (Journal Impact Factor)

  • Ano 2018
  • Factor de impacto da revista: 1.284
  • Factor de impacto sen autocitas: 1.22
  • Article influence score: 0.372
  • Cuartil maior: Q3
  • Área: DENTISTRY, ORAL SURGERY & MEDICINE Cuartil: Q3 Posición na área: 65/91 (Edición: SCIE)

SCImago Journal Rank

  • Ano 2018
  • Impacto SJR da revista: 0.623
  • Cuartil maior: Q2
  • Área: Otorhinolaryngology Cuartil: Q2 Posición na área: 39/122
  • Área: Medicine (miscellaneous) Cuartil: Q2 Posición na área: 1094/2950
  • Área: Surgery Cuartil: Q2 Posición na área: 153/491
  • Área: Dentistry (miscellaneous) Cuartil: Q2 Posición na área: 39/149

Scopus CiteScore

  • Ano 2018
  • CiteScore da revista: 2.7
  • Área: Dentistry (all) Percentil: 75
  • Área: Surgery Percentil: 68
  • Área: Otorhinolaryngology Percentil: 67

Journal Citation Indicator (JCI)

  • Ano 2018
  • JCI da revista: 0.76
  • Cuartil maior: Q2
  • Área: DENTISTRY, ORAL SURGERY & MEDICINE Cuartil: Q2 Posición na área: 62/147


(Datos actualizados na data de 31-03-2023)
  • Total de citas: 28
  • Citas recentes: 18
  • Relative Citation Ratio (RCR): 2.58
  • Field Citation Ratio (FCR): 9.27


Oral leukoplakia is the most common potentially malignant disorder (PMD) of the oral cavity. The objectives of this study are to determine the clinicopathologic features in a group of patients with oral leukoplakia of Northern Spain (Galicia), determining the factors associated to clinical risk and analyzing the malignant transformation of these patients. We included 85 patients. We recorded sex and age, habits like alcohol and tobacco, size, clinical appearance, site, number of lesions, and presence or absence of dysplasia. We assess the association between risk factors and transformation and developed a logistic regression analysis. Finally we used the Kaplan-Meier and log-rank test for the survival analysis. 7 patients (8.2%) had malignant transformation. The mean follow-up of the patients was 4.13 years versus 5.58 years of those who developed carcinoma. Only location and initial dysplasia have a statistically significant relationship with malignant transformation, but when applied the long rank test only the presence of dysplasia remains statistically significant(P<0,026). Oral Cancer Free Survival was 81.9% (0.150) at 11 years for the group without dysplasia. We found that the presence of dysplasia is the only risk factor that is statistically related to the development of a carcinoma.

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