The sea lamprey GABAB receptorChanges after spinal cord injury and its role in axonal regeneration

  1. Romaus Sanjurjo, Daniel
Dirixida por:
  1. María Celina Rodicio Director
  2. Antón Barreiro Iglesias Co-director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 20 de abril de 2018

Tribunal:
  1. Ramon Anadon Vazquez Presidente
  2. Idoia Quintana Urzainqui Secretario/a
  3. Arsenio Fernández López Vogal
Departamento:
  1. Departamento de Bioloxía Funcional

Tipo: Tese

Teseo: 549817 DIALNET lock_openAcceso aberto editor

Resumo

Spinal cord injury (SCI) causes irreversible loss of function. In contrast to mammals, lampreys show an amazing capacity for spontaneous recovery after a complete SCI. In this study, we analysed the changes in the expression of both gabab subunits after a complete SCI. Our results showed that plastic changes in this system probably contribute to the recovery of function after SCI in lampreys. Pharmacological and genetic manipulations revealed that GABA acting through GABAB receptors promotes axonal regeneration of descending neurons after a complete SCI in lampreys.